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Acute renal failure associated with intraperitoneal cisplatin chemotherapy with systemic thiosulfate protection in ovarian cancer patients.

Authors
  • Menczer, J1
  • Ben-Baruch, G
  • Rizel, S
  • Brenner, H
  • 1 Department of Obstetrics, Gynecology, and Oncology, Sheba Medical Center, Tel Hashomer, Israel.
Type
Published Article
Journal
European journal of gynaecological oncology
Publication Date
1991
Volume
12
Issue
5
Pages
403–406
Identifiers
PMID: 1915467
Source
Medline
License
Unknown

Abstract

Acute renal failure associated with intraperitoneal cisplatin chemotherapy occurred in 4 courses of treatment each given to one patient, and comprised 3.4% of the total number of intraperitoneal treatment courses. The 4 patients recovered completely, 2 of them after dialysis. Several possible reasons for this complication, which occurred in spite of thiosulphate systemic protection, are considered. Strict adherence to the treatment protocol is mandatory in order to avoid severe nephrotoxicity.

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