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Acute regulation of the facilitative glucose transporter GLUT1 in a hematopoietic cell line.

Authors
  • Hakim, Gabriele
  • Fiorentini, Diana
  • Maraldi, Tullia
  • Landi, Laura
Type
Published Article
Journal
The Italian journal of biochemistry
Publication Date
Dec 01, 2004
Volume
53
Issue
4
Pages
135–140
Identifiers
PMID: 15997905
Source
Medline
License
Unknown

Abstract

This brief review is focused on the short-term regulation of the facilitative glucose transporter GLUT1 in megakaryocytic cells M07e. The effects of cytokines such as TPO, GM-CSF and SCF and of a low dose of H202 on the transport activity and its kinetic parameters are compared. The possible mechanisms and the signalling pathways involved in the glucose uptake activation are discussed. A role for the cellular redox status in glucose uptake control, possibly related to the status of redox-sensitive enzymes such as tyrosine phosphatases, is suggested.

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