Acute regulation of the facilitative glucose transporter GLUT1 in a hematopoietic cell line.
- Authors
- Type
- Published Article
- Journal
- The Italian journal of biochemistry
- Publication Date
- Dec 01, 2004
- Volume
- 53
- Issue
- 4
- Pages
- 135–140
- Identifiers
- PMID: 15997905
- Source
- Medline
- License
- Unknown
Abstract
This brief review is focused on the short-term regulation of the facilitative glucose transporter GLUT1 in megakaryocytic cells M07e. The effects of cytokines such as TPO, GM-CSF and SCF and of a low dose of H202 on the transport activity and its kinetic parameters are compared. The possible mechanisms and the signalling pathways involved in the glucose uptake activation are discussed. A role for the cellular redox status in glucose uptake control, possibly related to the status of redox-sensitive enzymes such as tyrosine phosphatases, is suggested.