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Acute phase protein response to viral infection and vaccination.

Authors
  • Perez, Luis1
  • 1 Instituto de Investigación Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE-IBMC), Universidad Miguel Hernández, UMH, Elche, Spain. Electronic address: [email protected] , (Spain)
Type
Published Article
Journal
Archives of Biochemistry and Biophysics
Publisher
Elsevier
Publication Date
Aug 15, 2019
Volume
671
Pages
196–202
Identifiers
DOI: 10.1016/j.abb.2019.07.013
PMID: 31323216
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Organisms respond in multiple ways to microbial infections. Pathogen invasion tipically triggers an inflammatory response where acute phase proteins (APP) have a key role. Pentraxins (PTX) are a family of highly conserved APP that play a part in the host defense against infection. The larger proteins of the family are simply named pentraxins, while c-reactive proteins (CRP) and serum amyloid proteins (SAA, SAP) are known as short pentraxins. Although high APP levels have been broadly associated with bacterial infections, there is a growing body of evidence revealing increased PTX, CRP and SAP expression upon viral infection. Furthermore, CRP, PTX and SAP have shown their potential as diagnostic markers and predictors of disease outcome. Likewise, the measurement of APP levels can be valuable to determine the efficacy of antiviral therapies and vaccines. From the practical point of view, the ability of APP to reduce viral infectivity has been observed in several virus-host models. This has prompted investigation efforts to assess the role of acute phase response proteins as immunoregulatory molecules and their potential as therapeutic reagents. This work aims to present an overview of the APP response to viral infections reviewing the current knowledge in the field. Copyright © 2019 Elsevier Inc. All rights reserved.

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