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Acute phase modulation of systemic insulin-like growth factor-1 and its binding proteins after major burn injuries.

Authors
  • Nedelec, Bernadette
  • de Oliveira, Ana
  • Garrel, Dominique R
Type
Published Article
Journal
Critical Care Medicine
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jun 01, 2003
Volume
31
Issue
6
Pages
1794–1801
Identifiers
PMID: 12794422
Source
Medline
License
Unknown

Abstract

Insulin-like growth factor-binding protein-3 proteolysis does not seem to be the mechanism by which systemic insulin-like growth factor-1 levels are reduced in major burn survivors. In vitro proteolysis of recombinant human glycosylated and nonglycosylated iodine-125 insulin-like growth factor-binding protein-3 does not reflect the in vivo situation in major burn survivors.

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