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Acute pancreatitis caused by closed duodenal loop in the rat.

Authors
  • Nevalainen, T J
  • Seppä, A
Type
Published Article
Journal
Scandinavian journal of gastroenterology
Publication Date
Jan 01, 1975
Volume
10
Issue
5
Pages
521–527
Identifiers
PMID: 1153948
Source
Medline
License
Unknown

Abstract

Closed duodenal loop was created in the rat by obstructing the duodenum on both sides of the common bile duct. Acute haemorrhagic pancreatitis developed in these animals within 24 hours. Increased serum amylase activity, pancreatic acinar cell necrosis, pancreatic oedema and haemorrhages, and intra-abdominal fat necroses, together with formation of ascites fluid containing high levels of amylase, were observed in the experimental animals. The findings support the view that reflux of the duodenal contents into the pancreatic duct is an important early pathogenetic mechanism in the development of acute pancreatitis. The closed-loop technique in the rat offers a simple and reliable experimental model for studies on acute pancreatitis.

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