We present a case of vinorelbine (VNR)-induced acute tumor pain. Oral control-release oxycodone was administered for cancer pain by iliac bone metastasis. In chemotherapy by combined use of VNR and gemcitabine, severe pain in groin, thigh and hip occurred immediately after infusion of VNR. Oral rapid-release oxycodone was administered but the pain lasted half an hour and then resolved spontaneously. In the following course of chemotherapy by same regimen, pre-medication of rapid-release oxycodone did not prevent the pain.