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Acute kidney injury and aging.

Authors
  • Chang-Panesso, Monica1
  • 1 Division of Nephrology, Washington University in St. Louis, St. Louis, MO, USA. [email protected]
Type
Published Article
Journal
Pediatric Nephrology
Publisher
Springer-Verlag
Publication Date
Oct 01, 2021
Volume
36
Issue
10
Pages
2997–3006
Identifiers
DOI: 10.1007/s00467-020-04849-0
PMID: 33411069
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Our aging population is growing and developing treatments for age-related diseases such as Alzheimer's and Parkinson's disease has taken on an increasing urgency and is accompanied by high public awareness. The already high and rising incidence of acute kidney injury (AKI) in the elderly, however, has received relatively little attention despite the potentially fatal outcomes associated with an episode of AKI in this age group. When discussing AKI and aging, one should consider two aspects: first, elderly patients have an increased susceptibility to an AKI episode, and second, they have decreased kidney repair after AKI given the high incidence of progression to chronic kidney disease (CKD). It is unclear if the same factors that drive the increased susceptibility to AKI could be playing a role in the decreased repair capacity or if they are totally different and unrelated. This review will examine current knowledge on the risk factors for the increased susceptibility to AKI in the elderly and will also explore potential aspects that might contribute to a decreased kidney repair response in this age group. © 2021. IPNA.

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