Affordable Access

Access to the full text

Acute inactivation of retromer and ESCPE-1 leads to time-resolved defects in endosomal cargo sorting

Authors
  • Evans, Ashley J.
  • Daly, James L.
  • Anuar, Anis N. K.
  • Simonetti, Boris
  • Cullen, Peter J.
Type
Published Article
Journal
Journal of Cell Science
Publisher
The Company of Biologists
Publication Date
Aug 03, 2020
Volume
133
Issue
15
Identifiers
DOI: 10.1242/jcs.246033
PMID: 32747499
PMCID: PMC7420817
Source
PubMed Central
Keywords
Disciplines
  • Research Article
License
Green

Abstract

Summary: Retromer, a master controller of endosomal cargo sorting, is deregulated in neurodegenerative disease. Here, we develop and apply a retromer knocksideways methodology to quantify endosomal cargo sorting upon acute perturbation.

Report this publication

Statistics

Seen <100 times