Affordable Access

Acute haemodynamic responses to inhaled nitric oxide and intravenous sildenafil in distal chronic thromboembolic pulmonary hypertension (CTEPH).

Authors
  • Suntharalingam, J1
  • Hughes, R J
  • Goldsmith, K
  • Doughty, N
  • George, P
  • Toshner, M
  • Sheares, K K
  • Pepke-Zaba, J
  • 1 Pulmonary Vascular Diseases Unit, Papworth Hospital NHS Trust, Papworth Everard, Cambridgeshire, CB3 8RE, UK.
Type
Published Article
Journal
Vascular pharmacology
Publication Date
Jun 01, 2007
Volume
46
Issue
6
Pages
449–455
Identifiers
PMID: 17368113
Source
Medline
License
Unknown

Abstract

Although all but one patient failed to fulfil the formal haemodynamic response criteria typically used in idiopathic pulmonary arterial hypertension (IPAH), subjects displayed significant acute responses to both iNO and sildenafil suggesting that increased vascular tone forms an important component of distal CTEPH. It is possible that these acute haemodynamic responses may translate to improved clinical outcomes, and thus further long term trials of sildenafil in distal CTEPH are warranted.

Report this publication

Statistics

Seen <100 times