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Acute fatal myeloencephalopathy after combined intrathecal chemotherapy in a child with acute lymphoblastic leukemia.

Authors
  • von der Weid, N X
  • de Crousaz, H
  • Beck, D
  • Deonna, T
  • Miklossy, J
  • Janzer, R C
Type
Published Article
Journal
Medical and pediatric oncology
Publication Date
Jan 01, 1991
Volume
19
Issue
3
Pages
192–198
Identifiers
PMID: 2023567
Source
Medline
License
Unknown

Abstract

We report a case of a fatal toxic encephalomyelopathy in a 12-year-old girl due to prophylactic intrathecal injection of methotrexate and cytosine arabinoside, with a characteristic progressive symptomatology leading to death after 28 days. The location and type of neuropathological changes support the hypothesis of a direct toxic effect of methotrexate and/or cytosine arabinoside on structures directly exposed to the cerebrospinal fluid.

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