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Acute effects of mitoxantrone on the template activity of isolated nuclei from the T-47D human breast tumor cell line.

Authors
  • Chegini, N
  • Safa, A R
  • Tseng, M T
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Jan 01, 1984
Volume
21
Issue
3
Pages
329–336
Identifiers
PMID: 6198072
Source
Medline
License
Unknown

Abstract

The effect of mitoxantrone on the template activity of nuclei isolated from the T-47D human breast tumor cell line was investigated. The results suggest that mitoxantrone significantly inhibits total RNA synthesis of these nuclei in a concentration-dependent manner. At low drug concentrations (10(-9) M and 10(-7) M) RNA synthesis was inhibited by 21.9% and 41% compared to control values, respectively. Greater inhibition was observed when the mitoxantrone concentration was increased to 10(-5) M or 10(-4) M (56% and 77%, respectively). Experiments utilizing alpha-amanitin revealed that mitoxantrone inhibits RNA polymerase II activity in a concentration-dependent manner.

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