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Acute and chronic effects of the M1/M4-preferring muscarinic agonist xanomeline on cocaine vs. food choice in rats.

Authors
  • Thomsen, Morgane
  • Fulton, Brian S
  • Caine, S Barak
Type
Published Article
Journal
Psychopharmacology
Publication Date
Feb 01, 2014
Volume
231
Issue
3
Pages
469–479
Identifiers
DOI: 10.1007/s00213-013-3256-9
PMID: 23995301
Source
Medline
License
Unknown

Abstract

In terms of xanomeline's potential for promoting abstinence from cocaine in humans, the findings were mixed. Xanomeline did produce reallocation of behavior from cocaine to food with a robust increase in food reinforcers earned at some cocaine/xanomeline dose combinations. However, effects appeared surmountable, and food-maintained behavior was also decreased at some xanomeline/cocaine dose combinations, suggesting clinical usefulness may be limited. These data nevertheless support the notion that chronic muscarinic receptor stimulation can reduce cocaine self-administration. Future studies should show whether ligands with higher selectivity for M1 or M1/M4 subtypes would be less limited by undesired effects and can achieve higher efficacy.

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