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[Acute cerebellar syndrome after treatment with 5-fluorouracil].

Authors
  • Barbieux, C1
  • Patri, B
  • Cerf, I
  • de Parades, V
  • 1 Service de médecine interne I, hôpital Boucicaut, Paris, France.
Type
Published Article
Journal
Bulletin du Cancer
Publisher
Elsevier
Publication Date
January 1996
Volume
83
Issue
1
Pages
77–80
Identifiers
PMID: 8672860
Source
Medline
License
Unknown

Abstract

We report on a case of 5-fluorouracil induced neurotoxicity during 5-fluorouracil cisplatin combination chemotherapy for advanced head and neck squamous cell carcinoma. The initial manifestations included an acute cerebellar syndrome and peripheral neuropathy. Computed tomography of the brain was normal. The results of nerve-conduction studies were compatible with the diagnosis of distal sensory neuropathy. The patient experienced improvement, without treatment, four weeks after cessation of chemotherapy. The role of cisplatin and alcohol abuse in this neurotoxic episode, can not yet completely be excluded.

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