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Acute cardiovascular effects of bitter orange extract (p-synephrine) consumed alone and in combination with caffeine in human subjects: A placebo-controlled, double-blind study.

Authors
  • Ratamess, Nicholas A1
  • Bush, Jill A1
  • Stohs, Sidney J2
  • Ellis, Nicole L1
  • Vought, Ira T1
  • O'Grady, Elizabeth A1
  • Kuper, Jeremy D1
  • Hasan, Saif B1
  • Kang, Jie1
  • Faigenbaum, Avery D1
  • 1 Department of Health and Exercise Science, The College of New Jersey, Ewing, NJ, 08628, USA. , (Jersey)
  • 2 School of Pharmacy and Health Professions, Creighton University, Omaha, NE, 68178, USA.
Type
Published Article
Journal
Phytotherapy Research
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jan 01, 2018
Volume
32
Issue
1
Pages
94–102
Identifiers
DOI: 10.1002/ptr.5953
PMID: 29047215
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The purpose was to examine cardiovascular responses to supplementation with p-synephrine alone and in combination with caffeine during quiet sitting. Sixteen subjects were given (in double-blind manner) either 103 mg of p-synephrine (S), 233 mg of caffeine +104 mg of p-synephrine (LC + S), 240 mg of caffeine (LC), 337 mg of caffeine +46 mg of p-synephrine (HC + S), 325 mg of caffeine (HC), or a placebo. The subjects sat quietly for 3 hr while heart rate (HR) and blood pressure were measured. Only HC + S and HC significantly increased mean systolic blood pressure (SBP) during the second hour and tended to increase mean SBP during the third hour. Mean diastolic blood pressure in S was significantly lower than the other trials during the first and second hours, and mean arterial pressure was significantly lower in S compared to the LC, LC + S, HC, and HC + S trials. No differences were observed in HR. Consumption of p-synephrine may acutely reduce diastolic blood pressure and mean arterial pressure and not affect SBP or HR during quiet sitting. The addition of p-synephrine to caffeine did not augment SBP or HR indicating that consumption of up to 104 mg of p-synephrine does not induce cardiovascular stress during quiet sitting. Copyright © 2017 John Wiley & Sons, Ltd.

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