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Activity of key enzymes in microsomal and mitochondrial membranes depends on the redox reactions involving lipid radicals.

Authors
  • Dmitriev, L F
Type
Published Article
Journal
Membrane & cell biology
Publication Date
Jul 01, 2001
Volume
14
Issue
5
Pages
649–662
Identifiers
PMID: 11699868
Source
Medline
License
Unknown

Abstract

The work reviews membrane processes, such as monooxygenase reaction and oxidative phosphorylation with special reference to hydroxylation of a xenobiotic benzo(a)pyrene and the effects of the radical scavenger propyl gallate and radical generator Fe2+ ions on the reaction kinetics. A possibility is discussed that tocopherol provides for the activity of the lipid-radical cycles involving cytochrome b5. The lipid-radical cycles protect membrane lipids from oxidation and control the kinetics of membrane processes. The NADPH oxidation energy is transformed into the energy of lipid pulsations and this energy is used for activation of membrane enzymes. To account for the role of lipid pulsations in membrane processes, a new parameter is introduced - the internal temperature. It is supposed that there should be the equilibrium between the pro- and antioxidant factors in the membranes, and the presence of exogenous antioxidants (propyl gallate etc.) should be considered as a negative factor.

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