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Activities of roxithromycin against Mycobacterium avium infections in human macrophages and C57BL/6 mice.

Authors
  • L Struillou
  • Y Cohen
  • N Lounis
  • G Bertrand
  • J Grosset
  • J L Vildé
  • J J Pocidalo
  • C Perronne
Publication Date
Apr 01, 1995
Source
PMC
Keywords
License
Unknown

Abstract

The activity of roxithromycin against three clinical isolates of Mycobacterium avium was compared with that of clarithromycin both in a model of infection of human monocyte-derived macrophages and in a model of established infection of C57BL/6 mice. In the cell culture model, roxithromycin and clarithromycin were bactericidal for strains MO-1 and N-92159 and bacteriostatic for strain N-93043. For the three strains, the differences between the intracellular activities of roxithromycin and clarithromycin were not singificant after 7 days of treatment. Mice were infected with the MO-1 strain. Drugs were given by gavage at a dosage of 200 mg/kg of body weight 6 days per week for 16 weeks starting 5 weeks after infection. At the end of treatment, clarithromycin was more effective than roxithromycin in lungs; roxithromycin was as effective as clarithromycin in spleens. Thus, the activity of roxithromycin was comparable to that of clarithromycin both in vitro and in vivo.

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