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Activators of protein kinase C selectively mediate cellular cytotoxicity to hypoxic cells and not aerobic cells.

Authors
  • Koong, A C
  • Chen, E Y
  • Kim, C Y
  • Giaccia, A J
Type
Published Article
Journal
International Journal of Radiation Oncology*Biology*Physics
Publisher
Elsevier
Publication Date
May 15, 1994
Volume
29
Issue
2
Pages
259–265
Identifiers
PMID: 8195017
Source
Medline
License
Unknown

Abstract

These studies suggest that accumulation of phospholipid breakdown products may be responsible for TPA induced cell killing, and that hypoxic cells differ from aerobic cells in their ability to tolerate these products.

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