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Activation of xenobiotic receptors: driving into the nucleus.

Authors
  • Li, Haishan
  • Wang, Hongbing
Type
Published Article
Journal
Expert Opinion on Drug Metabolism & Toxicology
Publisher
Informa UK (Taylor & Francis)
Publication Date
Apr 01, 2010
Volume
6
Issue
4
Pages
409–426
Identifiers
DOI: 10.1517/17425251003598886
PMID: 20113149
Source
Medline
License
Unknown

Abstract

Nuclear accumulation is an essential step in the activation of XRs. Although great strides have been made, much remains to be understood concerning the mechanisms underlying intracellular localization and trafficking of XRs, which involve both direct ligand-binding and indirect pathways.

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