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The activation trajectory of plasmacytoid dendritic cells in vivo during a viral infection

Authors
  • Abbas, Abdenour1, 2
  • Vu Manh, Thien-Phong1
  • Valente, Michael1
  • Collinet, Nils1
  • Attaf, Noudjoud1
  • Dong, Chuang1
  • Naciri, Karima1
  • Chelbi, Rabie1
  • Brelurut, Geoffray3
  • Cervera-Marzal, Inaki1, 4
  • Rauwel, Benjamin5
  • Davignon, Jean-Luc5
  • Bessou, Gilles1
  • Thomas-Chollier, Morgane3
  • Thieffry, Denis3
  • Villani, Alexandra-Chloé6, 7
  • Milpied, Pierre1
  • Dalod, Marc1
  • Tomasello, Elena1
  • 1 Aix-Marseille University, CNRS, INSERM, CIML, Centre d’Immunologie de Marseille-Luminy, Turing Center for Living Systems, Marseille, France , Marseille (France)
  • 2 PSL Research University, Paris, France , Paris (France)
  • 3 École normale supérieure, CNRS, INSERM, Université PSL, Paris, France , Paris (France)
  • 4 Eura Nova, Marseille, France , Marseille (France)
  • 5 Centre de Physiopathologie Toulouse Purpan, Toulouse, France , Toulouse (France)
  • 6 Broad Institute of MIT and Harvard, Cambridge, MA, USA , Cambridge (United States)
  • 7 Massachusetts General Hospital, Boston, MA, USA , Boston (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Jul 20, 2020
Volume
21
Issue
9
Pages
983–997
Identifiers
DOI: 10.1038/s41590-020-0731-4
Source
Springer Nature
License
Yellow

Abstract

Plasmacytoid dendritic cells (pDCs) are a major source of type I interferon (IFN-I). Dalod and colleagues show that IFN-I production and T cell activation were performed by the same pDC, but these occurred sequentially and in different micro-anatomical locations during virus infection.

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