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Activation of Sirtuin 3 and Maintenance of Mitochondrial Integrity by N-Acetylcysteine Protects Against Bisphenol A-Induced Kidney and Liver Toxicity in Rats

Authors
  • Peerapanyasut, Wachirasek
  • Kobroob, Anongporn
  • Palee, Siripong
  • Chattipakorn, Nipon
  • Wongmekiat, Orawan
Publication Date
Jan 11, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

-SIRT3 signaling protein expressions, which led to decreased acetylation of superoxide dismutase 2 (SOD2) and increased expression of mitochondrial antioxidant manganese superoxide dismutase (MnSOD). The findings demonstrate the efficacy of NAC in protecting BPA-induced kidney and liver injury, which, in part, is mediated by activating SIRT3 and improving mitochondrial function, dynamics, and oxidative imbalance.

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