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Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway

Authors
  • Liu, Siwen1, 2
  • Huang, Suling1
  • Wu, Xingde3
  • Feng, Ying1
  • Shen, Yu1
  • Zhao, Qin-shi3
  • Leng, Ying1, 2
  • 1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, PR China
  • 2 University of Chinese Academy of Sciences, Beijing, 100049, PR China
  • 3 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China
Type
Published Article
Journal
Molecular Metabolism
Publisher
Elsevier BV
Publication Date
Jun 26, 2020
Volume
41
Identifiers
DOI: 10.1016/j.molmet.2020.101045
PMID: 32599076
PMCID: PMC7381706
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Phanginin A inhibits gluconeogenesis in primary mouse hepatocytes. • Phanginin A increases hepatic SIK1 phosphorylation both in vitro and in vivo . • Activation of SIK1 increases PDE4 activity and suppresses the cAMP signaling pathway. • Activation of SIK1 inhibits gluconeogenesis by regulating the PDE4/cAMP/PKA/CREB pathway. • Phanginin A improves metabolic disorders in ob/ob mice.

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