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The activation peptide of pancreatic procolipase decreases food intake in rats.

Authors
Type
Published Article
Journal
Regulatory Peptides
0167-0115
Publisher
Elsevier
Publication Date
Volume
22
Issue
4
Pages
325–331
Identifiers
PMID: 3187077
Source
Medline
License
Unknown

Abstract

Pancreatic procolipase is a cofactor for lipase and necessary for optimal fat digestion in the intestine during a meal. It is activated by trypsin in the intestine during release of an activation peptide, with the sequence Val-Pro-Asp-Pro-Arg in rat. This peptide, in the following termed VPDPR, was found to decrease food intake in rats. The human procolipase activation peptide with the sequence Ala-Pro-Gly-Pro-Arg (APGPR) had no effect on food intake in rats, nor the trypsinogen activation peptide with the sequence Phe-Pro-Val-Asp-Asp-Asp-Asp-Lys (FPVDDDDK). Procolipase added to standard pellets decreased the daily food intake in rats, whereas colipase added to pellets had no effect.

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