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Activation of the mTOR pathway in primary medullary thyroid carcinoma and lymph node metastases.

Authors
  • Tamburrino, Anna
  • Molinolo, Alfredo A
  • Salerno, Paolo
  • Chernock, Rebecca D
  • Raffeld, Mark
  • Xi, Liqiang
  • Gutkind, J Silvio
  • Moley, Jeffrey F
  • Wells, Samuel A Jr
  • Santoro, Massimo
Type
Published Article
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Date
Jul 01, 2012
Volume
18
Issue
13
Pages
3532–3540
Identifiers
DOI: 10.1158/1078-0432.CCR-11-2700
PMID: 22753663
Source
Medline
License
Unknown

Abstract

The AKT/mTOR pathway is activated in MTC, particularly, in LNMs. This pathway sustains malignant features of MTC cell models. These findings suggest that targeting mTOR might be efficacious in patients with advanced MTC.

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