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Activation of MMP-2 and MMP-9 in patients with oral squamous cell carcinoma.

Authors
  • Patel, Beena P1
  • Shah, Pankaj M
  • Rawal, Upendra M
  • Desai, Amisha A
  • Shah, Shakuntala V
  • Rawal, Rakesh M
  • Patel, Prabhudas S
  • 1 Biochemistry Research Division, The Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, India.
Type
Published Article
Journal
Journal of surgical oncology
Publication Date
May 01, 2005
Volume
90
Issue
2
Pages
81–88
Identifiers
PMID: 15844188
Source
Medline
License
Unknown

Abstract

The study concluded that activation of MMP-2 and MMP-9 was significantly higher in malignant tissues as compared to adjacent normal tissues. Further, activation ratio of MMP-2 was significantly elevated in patients with lymph node metastasis as compared to patients without lymph node metastasis, which could predict risk of lymph node metastasis development in node negative patients.

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