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Activation of the Cbl insulin signaling pathway in cardiac muscle; dysregulation in obesity and diabetes.

Authors
  • Gupte, Anisha
  • Mora, Silvia
Type
Published Article
Journal
Biochemical and biophysical research communications
Publication Date
Apr 14, 2006
Volume
342
Issue
3
Pages
751–757
Identifiers
PMID: 16494846
Source
Medline
License
Unknown

Abstract

In adipocytes, the Cbl/CAP dependent signaling pathway has been involved in regulating insulin-stimulated glucose uptake. We investigated activation of Cbl and its downstream effector TC10 in cardiac and skeletal muscle of Balb/C mice. Insulin administration resulted in Cbl phosphorylation in cardiac, skeletal muscle, and adipose tissue. Subsequent TC10 activation was detected only in heart and adipose tissue. c-Cbl and CAP gene expression was significantly reduced in the heart tissue of streptozotocin-induced diabetic animals, whereas no change was observed for other components of the pathway. No changes in Cbl expression were detected in hindlimb muscle. In leptin-/- obese mice Cbl expression in heart and adipose tissue was maintained, although insulin-mediated Cbl phosphorylation and subsequent TC10 activation were significantly reduced. In conclusion, our data demonstrate that Cbl/CAP/TC10 insulin signaling pathway is active in cardiac muscle and impaired during obesity and insulin deficiency.

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