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Activation of acetaminophen oxidation in rat liver microsomes by caffeine.

Authors
  • Nouchi, T
  • Lasker, J M
  • Lieber, C S
Type
Published Article
Journal
Toxicology Letters
Publisher
Elsevier
Publication Date
Jan 01, 1986
Volume
32
Issue
1-2
Pages
1–8
Identifiers
PMID: 3738921
Source
Medline
License
Unknown

Abstract

Addition of caffeine in vitro stimulated the oxidative metabolism of acetaminophen by rat liver microsomes, resulting in increased formation of acetaminophen-glutathione (GSH) conjugates and increased covalent binding of acetaminophen to microsomal protein. This metabolic enhancement by caffeine was most prominent using liver microsomes from phenobarbital (PB)-treated rats. Liver microsomes obtained from rats treated with ethanol-oxidized acetaminophen at much faster rates than microsomes from control, PB-treated or 3-methylcholanthrene (3-MC)-treated animals. The stimulatory effect of caffeine was, however, minimal in liver microsomes obtained from ethanol-treated rats.

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