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Activating brown adipose tissue for weight loss and lowering of blood glucose levels: a microPET study using obese and diabetic model mice.

Authors
  • Wu, Chenxi1
  • Cheng, Wuying1
  • Sun, Yi1
  • Dang, Yonghong1
  • Gong, Fengying2
  • Zhu, Huijuan2
  • Li, Naishi2
  • Li, Fang1
  • Zhu, Zhaohui1
  • 1 Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. , (China)
  • 2 Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. , (China)
Type
Published Article
Journal
PLoS ONE
Publisher
Public Library of Science
Publication Date
Jan 01, 2014
Volume
9
Issue
12
Identifiers
DOI: 10.1371/journal.pone.0113742
PMID: 25462854
Source
Medline
License
Unknown

Abstract

The inhibited BAT function in obese and DM mice can be re-activated by β3-adrenergic receptor agonist or thyroid hormone, and effective BAT activation may lead to weight loss and blood glucose lowering. Activating BAT can provide a new treatment strategy for obesity and DM.

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