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Activated protein C improves lipopolysaccharide-induced cardiovascular dysfunction by decreasing tissular inflammation and oxidative stress.

Authors
  • Sennoun, Nacira
  • Nacira, Sennoun
  • Meziani, Ferhat
  • Dessebe, Olivier
  • Cattan, Valérie
  • Collin, Solène
  • Montemont, Chantal
  • Gibot, Sebastien
  • Asfar, Pierre
  • Ramaroson, Andriantsitohaina
  • Andriantsitohaina, Ramaroson
  • Regnault, Veronique
  • Slama, Michel
  • Lecompte, Thomas
  • Lacolley, Patrick
  • Levy, Bruno
Type
Published Article
Journal
Critical Care Medicine
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jan 01, 2009
Volume
37
Issue
1
Pages
246–255
Identifiers
DOI: 10.1097/CCM.0b013e318192fe4f
PMID: 19112282
Source
Medline
License
Unknown

Abstract

These data suggest that APC improves cardiovascular function: 1) by modulating the endotoxin induced-proinflammatory/prooxidant state, 2) by decreasing endothelial/leukocyte interaction and 3) by favoring stabilization of the extracellular matrix.

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