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Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin.

Authors
  • Buckle, Guy J
  • Höllsberg, Per
  • Hafler, David A
Type
Published Article
Journal
Neurology
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Feb 25, 2003
Volume
60
Issue
4
Pages
702–705
Identifiers
PMID: 12601116
Source
Medline
License
Unknown

Abstract

The authors compared the functional activation state and cytokine secretion profile of CD8+ T cells in patients with relapsing-remitting and secondary progressive (SP) MS to those in normal controls. In addition, they examined cytokine secretion in relationship to single nucleotide polymorphism (SNP) analysis of cytokine genes. A significant increase in lymphotoxin secretion from anti-CD3-stimulated CD8+ T cells was observed in patients with SPMS as compared to normal controls. The authors found no significant differences in SNP frequency or in secretion of other cytokines.

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