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Action potentials in retinal ganglion cells are initiated at the site of maximal curvature of the extracellular potential.

Authors
Type
Published Article
Journal
Journal of Neural Engineering
1741-2552
Publisher
IOP Publishing
Publication Date
Volume
11
Issue
3
Pages
36006–36006
Identifiers
DOI: 10.1088/1741-2560/11/3/036006
PMID: 24762943
Source
Medline
License
Unknown

Abstract

We present a framework how to estimate the site of action potential initiation and the stimulus required to cross threshold in neurons tightly interfaced to capacitive stimulation electrodes. Our results underscore the necessity of rigorous electrical characterization of the stimulation electrodes and of the interfaced neural tissue.

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