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Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6.

Authors
  • Sirish, Padmini1
  • Ledford, Hannah A1
  • Timofeyev, Valeriy1
  • Thai, Phung N1
  • Ren, Lu1
  • Kim, Hyo Jeong1
  • Park, Seojin1
  • Lee, Jeong Han1
  • Dai, Gu1
  • Moshref, Maryam1
  • Sihn, Choong-Ryoul1
  • Chen, Wei Chun1
  • Timofeyeva, Maria Valeryevna1
  • Jian, Zhong1
  • Shimkunas, Rafael1
  • Izu, Leighton T1
  • Chiamvimonvat, Nipavan1
  • Chen-Izu, Ye1
  • Yamoah, Ebenezer N1
  • Zhang, Xiao-Dong2
  • 1 From the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
  • 2 From the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.). [email protected]
Type
Published Article
Journal
Circulation Arrhythmia and Electrophysiology
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Oct 01, 2017
Volume
10
Issue
10
Identifiers
DOI: 10.1161/CIRCEP.117.005267
PMID: 29025768
Source
Medline
Keywords
License
Unknown

Abstract

Our study provides mechanistic insights into Slc26a6, a unique cardiac electrogenic Cl-/HCO3- transporter in ventricular myocytes, linking the critical roles of Slc26a6 in regulation of pHi, excitability, and contractility. pHi is a critical regulator of other membrane and contractile proteins. Future studies are needed to investigate possible changes in these proteins in Slc26a6-/- mice.

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