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Action of leishmanial excreted factor (EF) on human lymphocyte blast transformation.

Authors
Type
Published Article
Journal
Parasite immunology
Publication Date
Volume
5
Issue
3
Pages
249–256
Identifiers
PMID: 6866562
Source
Medline
License
Unknown

Abstract

The effect of Leishmania tropica major excreted factor (EF) on human immune and normal mononuclear peripheral blood cells has been studied. The response of lymphocytes to stimulation either specifically with leishmanial antigens or non-specifically with phytohemagglutinin (PHA) in the presence of EF was tested by the uptake of 3 [H]thymidine. The results showed that EF inhibits the response of cells from immune donors to leishmanial antigens and from normal donors to PHA or PPD. Adherent and non-adherent cells were separated and the effect of EF on both populations was analysed. The results showed that EF inhibited blast transformation if both EF and antigen were presented to each of the separate populations. The inhibition of the adherent cells (mainly monocytes) was more marked than the inhibition of the non-adherent population (mainly lymphocytes).

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