The actin-binding protein palladin associates with the respiratory syncytial virus matrix protein
- Authors
- Type
- Published Article
- Journal
- Journal of Virology
- Publisher
- American Society for Microbiology
- Publication Date
- Oct 03, 2024
- Volume
- 98
- Issue
- 10
- Identifiers
- DOI: 10.1128/jvi.01435-24
- Source
- ASM Journals
- Keywords
- License
- Green
Abstract
Respiratory syncytial virus is responsible for severe lower respiratory tract infections in young children under 5 years old, the elderly, and the immunosuppressed. The interaction of the respiratory syncytial virus matrix protein with the host actin cytoskeleton is important in infection but has not been investigated in depth. In this study, we show that the respiratory syncytial virus matrix protein associates with actin microfilaments and the actin-binding protein palladin, suggesting a role for palladin in respiratory syncytial virus release. This study provides new insight into the role of the actin cytoskeleton in respiratory syncytial virus infection, a key host–RSV interaction in assembly. Understanding the mechanism by which the RSV M protein and actin interact will ultimately provide a basis for the development of therapeutics targeted at RSV infections.
