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γ-Actin plays a key role in endothelial cell motility and neovessel maintenance.

Authors
  • Pasquier, Eddy
  • Tuset, Maria-Pia
  • Sinnappan, Snega
  • Carnell, Michael
  • Macmillan, Alexander
  • Kavallaris, Maria
Type
Published Article
Journal
Vascular Cell
Publisher
Publiverse Online S.R.L
Publication Date
Jan 01, 2015
Volume
7
Pages
2–2
Identifiers
DOI: 10.1186/s13221-014-0027-2
PMID: 25705373
Source
Medline
Keywords
License
Unknown

Abstract

Our study thus demonstrates for the first time that β-actin is essential for endothelial cell survival and γ-actin plays a crucial role in angiogenesis, through both ROCK-dependent and -independent mechanisms. This provides new insights into the role of the actin cytoskeleton in angiogenesis and may open new therapeutic avenues for the treatment of angiogenesis-related disorders.

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