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Acrylate-endcapped urethane-based hydrogels: An in vivo study on wound healing potential.

Authors
  • Ionescu, Oana Maria1
  • Mignon, Arn2
  • Minsart, Manon3
  • Caruntu, Irina-Draga4
  • Giusca, Simona Eliza4
  • Gardikiotis, Ioannis5
  • Van Vlierberghe, Sandra6
  • Profire, Lenuta7
  • 1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy of Iasi, 16 University Street, Iasi 700115, Romania. , (Oman)
  • 2 Polymer Chemistry and Biomaterials Group, Center of Macromolecular Chemistry, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-bis, 9000 Gent, Belgium; Smart Polymeric Biomaterials, Biomaterials and Tissue Engineering, Campus Group T, KU Leuven, Andreas Vesaliusstraat 13, 3000 Leuven, Belgium. , (Belgium)
  • 3 Polymer Chemistry and Biomaterials Group, Center of Macromolecular Chemistry, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-bis, 9000 Gent, Belgium. , (Belgium)
  • 4 Department of Morphofunctional Sciences, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy of Iasi, 16 University Street, Iasi 700115, Romania. , (Oman)
  • 5 Advanced Centre of Research and Development in Experimental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy of Iasi, 16 University Street, Iasi 700115, Romania. , (Oman)
  • 6 Polymer Chemistry and Biomaterials Group, Center of Macromolecular Chemistry, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-bis, 9000 Gent, Belgium. Electronic address: [email protected] , (Belgium)
  • 7 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy of Iasi, 16 University Street, Iasi 700115, Romania. Electronic address: [email protected]fiasi.ro. , (Oman)
Type
Published Article
Journal
Materials science & engineering. C, Materials for biological applications
Publication Date
Nov 01, 2021
Volume
130
Pages
112436–112436
Identifiers
DOI: 10.1016/j.msec.2021.112436
PMID: 34702521
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Improving wound healing by developing innovative dressing materials has been an important focus over the past few years in the biomedical field. In this regard, the current study focuses on developing new dressings based on acrylate-endcapped urethane-based polymers (AUPs). The materials have been processed into films and electrospun mats. Exudate uptake capacity, mechanical properties and fiber morphology were evaluated herein. The results showed superior uptake capacity of both films and mats when compared to Aquacel®Ag, Exufiber® and Help®. Addition of a high molar mass poly(ethylene glycol) to the AUP polymers benefits both the film and electrospun dressings in terms of flexibility and elongation. An in vivo study was conducted to assess the wound healing properties of these dressings on an acute wound model induced to rats. A macroscopic evaluation indicated that wound contraction and wound fraction percentages were improved significantly in case of the AUP-materials when compared to both the positive (Aquacel®Ag) and negative (Exufiber® and Help®) controls. A histopathological assay, to underline the changes noticed on a macroscopical level, was also performed. The data obtained proved that the developed dressings are beneficial towards tissue regeneration and accelerated wound healing. These findings offer a practical yet adequate strategy for the fabrication of acrylate-endcapped urethane-based materials for wound healing applications. Copyright © 2021 Elsevier B.V. All rights reserved.

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