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Acridine: A Scaffold for the Development of Drugs for Alzheimer's Disease.

Authors
  • Sharma, Anuradha1
  • Piplani, Poonam2
  • 1 Faculty of Pharmaceutical Sciences, PCTE Group of Institute, Baddowal, Ludhiana India. , (India)
  • 2 Department of Pharmaceutical Chemistry, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. , (India)
Type
Published Article
Journal
Current topics in medicinal chemistry
Publication Date
Jan 01, 2023
Volume
23
Issue
13
Pages
1260–1276
Identifiers
DOI: 10.2174/1568026623666230203141543
PMID: 36740790
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Alzheimer's disease (AD) is drawing scientists' consideration, being one of the gravest diseases mankind will have to battle against in the near future. The number of people with AD is expected to triple in the next 40 years. It is a most common age-related multifactorial neurodegenerative disease and characterized by two histopathological hallmarks; the formation of senile plaques composed of the amyloid-β (Aβ) peptide and neurofibrillary tangles composed of hyperphosphorylated tau protein. Discovery and development of rationally designed multi-targeted ligands for the management of AD could be more beneficial than classical single targeted molecules. Acridine, a heterocyclic nucleus is a sole moiety in various existing drug molecules such as quinacrine (antimalarial), acriflavine and proflavine (antiseptics), ethacridine (abortifacient), amsacrine and nitracine (anticancer) and tacrine (anti-Alzheimer). It is proposed that acridine may combat the AD by acting on several targets like acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), dual specificity tyrosine kinase 1A (Dyrk 1A), amyloid and prion protein (PrPC) etc. involved in its pathogenesis. The main aim of this compilation is to review the most promising therapeutic developments within the vast research area dealing with acridine derivatives. Further research is required to evaluate the effectiveness of the acridine derivatives with various substitutions in the treatment of AD. In conclusion, our review will suggest the potentiality of the versatile acridine framework for drug designing and developing novel multi-target inhibitors for the Alzheimer's disease. Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

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