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Acquisition of the rheumatoid arthritis HLA shared epitope through microchimerism.

Authors
  • Yan, Zhen
  • Aydelotte, Tessa
  • Gadi, V K
  • Guthrie, Katherine A
  • Nelson, J Lee
Type
Published Article
Journal
Arthritis & Rheumatism
Publisher
Wiley (John Wiley & Sons)
Publication Date
Mar 01, 2011
Volume
63
Issue
3
Pages
640–644
Identifiers
DOI: 10.1002/art.30160
PMID: 21360493
Source
Medline
License
Unknown

Abstract

These results indicate that RA patients who genotypically lack the SE can acquire the SE as persistent microchimerism from fetal-maternal cell exchange, suggesting that SE-encoding microchimerism could be a risk factor for RA.

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