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Acquired versus intrinsic resistance to methotrexate: diversity of the drug-resistant phenotype in mammalian cells.

Authors
  • Melera, P W
Type
Published Article
Journal
Seminars in cancer biology
Publication Date
Aug 01, 1991
Volume
2
Issue
4
Pages
245–255
Identifiers
PMID: 1912529
Source
Medline
License
Unknown

Abstract

The expression of resistance by tumor cells to anticancer drugs remains a primary cause of patient failure to chemotherapeutic intervention in cancer. Although studied for many years, both the acquisition and maintenance of drug resistance continue to provide active areas for research and the application of modern molecular and cell biological techniques to those questions has begun to generate a wealth of new information. This article attempts to summarize and contrast some of the more recent observations concerning acquired and intrinsic resistance to the classical antifolate methotrexate, and suggests that the mechanisms of intrinsic resistance, and to a lesser extent acquired resistance as well, may be more broad based than previously thought and that the expression of intrinsic resistance may be strongly influenced by physiological and genetic variation.

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