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Acquired factor V inhibitor in a patient with mantle cell lymphoma presenting with hematuria followed by thrombosis: a case report.

Authors
  • Aljohani, Naif I1
  • Matthews, John H2
  • 1 King Faisal specialist hospital and research centre, Saudi Arabia ; Division of Hematology, Department of Internal Medicine, Queen's University, Kingston, Ontario, Canada. , (Canada)
  • 2 Division of Hematology, Department of Internal Medicine, Queen's University, Kingston, Ontario, Canada. , (Canada)
Type
Published Article
Journal
International Medical Case Reports Journal
Publisher
Dove
Publication Date
Jan 01, 2014
Volume
7
Pages
27–30
Identifiers
DOI: 10.2147/IMCRJ.S59236
PMID: 24591851
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Acquired factor V inhibitor is a rare hemostatic disorder that presents with hemorrhagic manifestations in the vast majority of patients. Factor V inhibitor may develop through a variety of mechanisms involving development of alloantibodies or autoantibodies specific to Factor V. Autoantibodies, in particular, have been reported in a number of conditions. In this report, we describe a case of acquired factor V inhibitor in a patient with mantle cell lymphoma who presented with hematuria. Seven weeks after diagnosis and successful management, the patient developed deep vein thrombosis in the right lower extremity. The patient's factor V levels were normalized, and the inhibitor was successfully eradicated using corticosteroids. Here, we discuss this rare disorder, its unusual manifestation, and provide a mini-review of the current literature regarding factor V inhibitors.

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