Affordable Access

deepdyve-link
Publisher Website

Acquired cystic kidney disease: an under-recognized condition in children with end-stage renal disease.

Authors
  • Chan, Eugene Y H1
  • Warady, Bradley A2
  • 1 Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO, 64108, USA.
  • 2 Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO, 64108, USA. [email protected]
Type
Published Article
Journal
Pediatric Nephrology
Publisher
Springer-Verlag
Publication Date
Jan 01, 2018
Volume
33
Issue
1
Pages
41–51
Identifiers
DOI: 10.1007/s00467-017-3649-9
PMID: 28444445
Source
Medline
Keywords
License
Unknown

Abstract

Acquired cystic kidney disease (ACKD) is a condition that occurs predominantly in patients with end-stage renal disease (ESRD). In contrast to hereditary cystic kidney disease, ACKD is characterized by the presence of multiple small cysts in bilaterally small kidneys. Limited pediatric data suggest a high incidence (21.6-45.8%) of ACKD in children on dialysis, comparable to that in adults, with an increased frequency associated with a longer duration of dialysis. Recent research has shed light on the pathogenesis of ACKD, such as activation of proto-oncogenes. Although most patients with ACKD are asymptomatic, the condition can be complicated by renal cell carcinoma. Routine surveillance should therefore be considered in at-risk populations.

Report this publication

Statistics

Seen <100 times