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ACNU-resistant mutants of 9L rat glioma cell line. Isolation and preliminary characterization of these subclones.

Authors
  • Kokunai, T
  • Tamaki, N
  • Matsumoto, S
Type
Published Article
Journal
Journal of neurosurgery
Publication Date
Oct 01, 1985
Volume
63
Issue
4
Pages
583–588
Identifiers
PMID: 3861792
Source
Medline
License
Unknown

Abstract

Three ACNU-resistant subclones were isolated and characterized from a wild-typed 9L rat glioma cell line in culture. At an early stage after cloning, these ACNU-resistant subclones showed a high frequency of chromosomal aberrations compared with nonresistant 9L cells. These ACNU-resistant subclones revealed a cross resistance to BCNU, CCNU, methyl CCNU, nitrogen mustard, cyclophosphamide, and cis-platinum, which are alkylating agents. Further studies are necessary to clarify the mechanisms of ACNU-resistance from the aspect of repair of DNA alkylation damage.

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