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Acid phospholipase A 1 and A 2 in the cells, and subcellular redistribution of their activities in the cells infected with measles virus

Authors
  • Suzuki, Y.
  • Matsumoto, M.
Type
Published Article
Journal
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Publication Date
Jan 01, 1974
Volume
57
Issue
2
Pages
505–512
Identifiers
DOI: 10.1016/0006-291X(74)90961-9
Source
Elsevier
Keywords
License
Unknown

Abstract

Presence of soluble acid phospholipase A 1 and A 2 was confirmed in the (lysosomes + mitochondria) fraction of cultured human amnion cell line, FL cells. Activity of these enzymes and acid phosphatase was detected in the cytosol fraction of FL cells harvested at 59 hr after infection with measles virus, indicating that these enzymes in the (lysosomes + mitochondria) fraction were released to the cytosol fraction during the maturation of measles virus in the cells. Further, it was confirmed that the release of acid phospholipase A 1 and A 2 almost paralleled the development of cytopathic effect.

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