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Achyranthes bidentata polypeptide protects dopaminergic neurons from apoptosis in Parkinson's disease models both in vitro and in vivo.

Authors
  • Peng, Su1
  • Wang, Caiping1
  • Ma, Jinyu1
  • Jiang, Ketao1
  • Jiang, Yuhui1
  • Gu, Xiaosong1
  • Sun, Cheng1
  • 1 Key Laboratory of Neuroregeneration of Jiangsu Province and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China. , (China)
Type
Published Article
Journal
British Journal of Pharmacology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Feb 01, 2018
Volume
175
Issue
4
Pages
631–643
Identifiers
DOI: 10.1111/bph.14110
PMID: 29181847
Source
Medline
License
Unknown

Abstract

Taken together, our data show that ABPPk protects dopaminergic neurons from apoptosis, suggesting that ABPPk might be an effective intervention for treating the neuron loss associated with disorders such as PD.

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