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Achiral and chiral high-performance liquid chromatographic determination of tramadol and its major metabolites in urine after oral administration of racemic tramadol.

Authors
  • Elsing, B
  • Blaschke, G
Type
Published Article
Journal
Journal of chromatography
Publication Date
Feb 26, 1993
Volume
612
Issue
2
Pages
223–230
Identifiers
PMID: 8468380
Source
Medline
License
Unknown

Abstract

A reversed-phase high-performance liquid chromatographic method for the simultaneous determination of tramadol and its major metabolites O-demethyltramadol and N-demethyltramadol in urine has been developed. The determination of the enantiomeric ratios of the three compounds was achieved using a Chiralpak AD column and a Chiralcel OD column, respectively. After oral administration of racemic tramadol to five healthy volunteers, inter-individual differences of the excreted amounts and the enantiomeric ratios of the compounds were observed.

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