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Achalasia and Obstructive Motor Disorders Are Not Uncommon in Patients With Eosinophilic Esophagitis.

Authors
  • Ghisa, Matteo1
  • Laserra, Giorgio1
  • Marabotto, Elisa2
  • Ziola, Sebastiano2
  • Tolone, Salvatore3
  • de Bortoli, Nicola4
  • Frazzoni, Marzio5
  • Mauro, Aurelio6
  • Penagini, Roberto7
  • Savarino, Vincenzo2
  • Barberio, Brigida1
  • Giannini, Edoardo Giovanni2
  • Zentilin, Patrizia2
  • Gyawali, C Prakash8
  • Savarino, Edoardo9
  • 1 Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy. , (Italy)
  • 2 Gastroenterology Unit, Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy. , (Italy)
  • 3 Surgery Unit, Department of Surgery, University of Campania Luigi Vanvitelli, Caserta, Italy. , (Italy)
  • 4 Gastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy. , (Italy)
  • 5 Pathophysiology Unit, Baggiovara Hospital, Modena, Italy. , (Italy)
  • 6 Gastroenterology and Endoscopy Unit, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy. , (Italy)
  • 7 Gastroenterology and Endoscopy Unit, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy. , (Italy)
  • 8 Division of Gastroenterology, Washington University School of Medicine in St Louis, St Louis, Missouri.
  • 9 Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy. Electronic address: [email protected] , (Italy)
Type
Published Article
Journal
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Publication Date
Aug 01, 2021
Volume
19
Issue
8
Pages
1554–1563
Identifiers
DOI: 10.1016/j.cgh.2020.07.056
PMID: 32763482
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

An association has been reported between achalasia and eosinophilic esophagitis (EoE). We performed a retrospective study of high-resolution manometry (HRM) patterns in a large cohort of patients with EoE. We collected data from consecutive patients with a new diagnosis of EoE from 2012 through 2019 undergoing HRM during the initial assessment at different centers in Italy. Demographic, clinical, endoscopic and histological characteristics were recorded at baseline and during management. Diagnoses of EoE and esophageal motility disorders were made according to established criteria. Treatments offered included proton pump inhibitors and topical steroids for EoE, and pneumatic dilation and myotomy for achalasia. Response to therapy was defined as less than 15 eosinophils per high power field in esophageal biopsies. Of 109 consecutive patients (mean age 37 years, 82 male), 68 (62%) had normal findings from HRM. Among 41 patients with motor disorders, 24 (59%) had minor motor disorders and 17 (41%) presented with major motor disorders, including 8 with achalasia (1 with type 1, 4 with type 2, and 3 with type 3). Achalasia and nonachalasia obstructive motor disorders had 14.7% prevalence among patients with EoE. Achalasia was more frequent in women, with longer diagnostic delay and abnormal esophagogram (P < .05) compared with EoE without achalasia or obstructive motor disorders. Clinical features and endoscopic findings did not differ significantly between patients with EoE with vs without achalasia and obstructive motor disorders. A higher proportion of patients without achalasia and obstructive motor disorders responded to topical steroids than patients with these features (P < .005). Invasive achalasia management was required for symptom relief in 50% of patients with achalasia and obstructive motor disorders. Achalasia and obstructive motor disorders are found in almost 15% of patients with EoE, and esophageal eosinophilia might cause these disorders. Patients with EoE who do not respond to standard treatments might require targeted muscle disruption. Copyright © 2021 AGA Institute. Published by Elsevier Inc. All rights reserved.

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