Affordable Access

Acetaminophen. Concepts and controversies.

Authors
  • Anker, A L
  • Smilkstein, M J
Type
Published Article
Journal
Emergency Medicine Clinics of North America
Publisher
Elsevier
Publication Date
May 01, 1994
Volume
12
Issue
2
Pages
335–349
Identifiers
PMID: 8187687
Source
Medline
License
Unknown

Abstract

APAP poisoning is common, and despite the availability of a specific antidote, fatalities still occur. Early treatment using NAC is highly effective in preventing liver injury, but further study is needed to determine optimum indications, route of administration, dosage, and duration of treatment. Recent advances have changed traditional concepts regarding late treatment and mechanisms of NAC action, but significant gaps in understanding persist. Immediate challenges include refining the diagnosis and treatment of APAP toxicity after repeated ingestions, defining settings in which deviation from standard protocols is appropriate, and improving therapy of APAP-induced hepatic failure.

Report this publication

Statistics

Seen <100 times