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Genetic disruption of protein phosphatase 5 in mice prevents high-fat diet feeding-induced weight gain

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
587
Issue
23
Identifiers
DOI: 10.1016/j.febslet.2013.10.022
Keywords
  • Diabetes
  • Protein Phosphatase 5
  • High-Fat Diet
  • Knockout Mouse
  • Obesity
  • Insulin Sensitivity
Disciplines
  • Biology

Abstract

Abstract The role of serine/threonine protein phosphatase 5 (PP5) in the development of obesity and insulin resistance associated with high-fat diet-feeding (HFD) was examined using PP5-deficient mice (Ppp5c−/−). Despite similar caloric intake, Ppp5c−/− mice on HFD gained markedly less weight and did not accumulate visceral fat compared to wild-type littermates (Ppp5c+/+). On a control diet, Ppp5c−/− mice had markedly improved glucose control compared to Ppp5c+/+ mice, an effect diminished by HFD. However, even after 10weeks of HFD glucose control in Ppp5c−/− mice was similar to that observed in Ppp5c+/+ mice on the control diet. Thus, PP5 deficiency confers protection against HFD-induced weight gain in mice.

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