Affordable Access

deepdyve-link
Publisher Website

Accuracy of single molecular biomarkers in gingival crevicular fluid for the diagnosis of periodontitis: A systematic review and meta-analysis.

Authors
  • Arias-Bujanda, Nora1
  • Regueira-Iglesias, Alba1
  • Balsa-Castro, Carlos1
  • Nibali, Luigi2
  • Donos, Nikos3
  • Tomás, Inmaculada1
  • 1 Oral Sciences Research Group, Department of Surgery and Medical Surgical Specialties, School of Medicine and Dentistry, Health Research Institute Foundation of Santiago (FIDIS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain. , (Spain)
  • 2 Periodontology Unit, Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK.
  • 3 Centre for Oral Immunobiology and Regenerative Medicine and Centre for Oral Clinical Research, Queen Mary University of London, London, UK.
Type
Published Article
Journal
Journal Of Clinical Periodontology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Dec 01, 2019
Volume
46
Issue
12
Pages
1166–1182
Identifiers
DOI: 10.1111/jcpe.13188
PMID: 31444912
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To analyse, by means of a meta-analytical approach, the diagnostic accuracy of molecular biomarkers in gingival crevicular fluid (GCF) for the detection of periodontitis in systemically healthy subjects. Studies on GCF molecular biomarkers providing a binary classification table (or sensitivity and specificity values and group sample sizes) in individuals with clinically diagnosed periodontitis were considered eligible. The search was performed using six electronic databases. The methodological quality of studies was assessed through the tool Quality Assessment of Diagnostic Studies. Meta-analyses were performed using the Hierarchical Summary Receiver Operating Characteristic, which adjusts classification data using random effects logistic regression. The included papers identified 36 potential biomarkers for the detection of periodontitis and for four of them meta-analyses were performed. The median sensitivity and specificity were for MMP8, 76.7% and 92.0%; for elastase, 74.6% and 81.1%; for cathepsin, 72.8% and 67.3%, respectively. The worst estimates of sensitivity and specificity were for trypsin (71.3% and 66.1%, respectively). MMP8 showed good sensitivity and excellent specificity, which resulted in this biomarker being clinically the most useful or effective for the diagnosis of periodontitis in systemically healthy subjects, regardless of smoking condition. © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Report this publication

Statistics

Seen <100 times