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Accelerated whole-brain perfusion imaging using a simultaneous multislice spin-echo and gradient-echo sequence with joint virtual coil reconstruction.

Authors
  • Manhard, Mary Kate1, 2
  • Bilgic, Berkin1, 2
  • Liao, Congyu1, 2
  • Han, SoHyun1, 2
  • Witzel, Thomas1, 2
  • Yen, Yi-Fen1, 2
  • Setsompop, Kawin1, 2, 3
  • 1 Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts.
  • 2 Department of Radiology, Harvard Medical School, Boston, Massachusetts.
  • 3 Harvard-MIT Health Sciences and Technology, MIT, Cambridge, Massachusetts.
Type
Published Article
Journal
Magnetic Resonance in Medicine
Publisher
Wiley (John Wiley & Sons)
Publication Date
Sep 01, 2019
Volume
82
Issue
3
Pages
973–983
Identifiers
DOI: 10.1002/mrm.27784
PMID: 31069861
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Dynamic susceptibility contrast imaging requires high temporal sampling, which poses limits on achievable spatial coverage and resolution. Additionally, more encoding-intensive multi-echo acquisitions for quantitative imaging are desired to mitigate contrast leakage effects, which further limits spatial encoding. We present an accelerated sequence that provides whole-brain coverage at an improved spatio-temporal resolution, to allow for dynamic quantitative R2 and R2 * mapping during contrast-enhanced imaging. A multi-echo spin and gradient-echo sequence was implemented with simultaneous multislice acquisition. Complementary k-space sampling between repetitions and joint virtual coil reconstruction were used along with a dynamic phase-matching technique to achieve high-quality reconstruction at 9-fold acceleration, which enabled 2 × 2 × 5 mm whole-brain imaging at TR of 1.5 to 1.7 seconds. The multi-echo images from this sequence were fit to achieve quantitative R2 and R2 * maps for each repetition, and subsequently used to find perfusion measures including cerebral blood flow and cerebral blood volume. Images reconstructed using joint virtual coil show improved image quality and g-factor compared with conventional reconstruction methods, resulting in improved quantitative maps with a 9-fold acceleration factor and whole-brain coverage during the dynamic perfusion acquisition. The method presented shows the advantage of using a joint virtual coil-GRAPPA reconstruction to allow for high acceleration factors while maintaining reliable image quality for quantitative perfusion mapping, with the potential to improve tumor diagnostics and monitoring. © 2019 International Society for Magnetic Resonance in Medicine.

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