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Accelerated complete human skin architecture restoration after wounding by nanogenerator-driven electrostimulation

Authors
  • Liu, Aiping1
  • Long, Yin1
  • Li, Jun1
  • Gu, Long1
  • Karim, Aos1
  • Wang, Xudong1
  • Gibson, Angela L. F.1
  • 1 University of Wisconsin-Madison,
Type
Published Article
Journal
Journal of Nanobiotechnology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Sep 20, 2021
Volume
19
Identifiers
DOI: 10.1186/s12951-021-01036-7
PMID: 34544434
PMCID: PMC8454068
Source
PubMed Central
Keywords
Disciplines
  • Research
License
Unknown

Abstract

Background Electrostimulation (ES) therapy for wound healing is limited in clinical use due to barriers such as cumbersome equipment and intermittent delivery of therapy. Methods We adapted a human skin xenograft model that can be used to directly examine the nanogenerator-driven ES (NG-ES) effects on human skin in vivo—an essential translational step toward clinical application of the NG-ES technique for wound healing. Results We show that NG-ES leads to rapid wound closure with complete restoration of normal skin architecture within 7 days compared to more than 30 days in the literature. NG-ES accelerates the inflammatory phase of wound healing with more rapid resolution of neutrophils and macrophages and enhances wound bed perfusion with more robust neovascularization. Conclusion Our results support the translational evaluation and optimization of the NG-ES technology to deliver convenient, efficient wound healing therapy for use in human wounds. Graphic abstract Supplementary Information The online version contains supplementary material available at 10.1186/s12951-021-01036-7.

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